CYP3A4 and pregnane X receptor humanized mice

@article{Gonzalez2007CYP3A4AP,
  title={CYP3A4 and pregnane X receptor humanized mice},
  author={Frank J. Gonzalez},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={2007},
  volume={21}
}
  • F. Gonzalez
  • Published 1 August 2007
  • Biology
  • Journal of Biochemical and Molecular Toxicology
Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic clones. In some cases, transgenic mice carrying the human genes are bred with null‐mice to produce fully humanized mice. Mice expressing human CYP1A1, CYP1A2… 

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