CYP3A4*1B polymorphism and cancer risk: A HuGE review and meta-analysis

  title={CYP3A4*1B polymorphism and cancer risk: A HuGE review and meta-analysis},
  author={Li-ping Zhou and Fan Yao and Hong Fen Luan and Yin-Ling Wang and Xi-Hua Dong and W W Zhou and Qi-hui Wang},
  journal={Tumor Biology},
CYP450 3A4 (CYP3A4), encoded by the CYP3A4 gene, is a major enzyme catalyzing the metabolism of both endogenous and exogenous agents that may play a role in the etiology of carcinogenesis. Several potentially functional polymorphisms of the CYP3A4 gene have been implicated in cancer risk, but individually published studies have shown inconclusive results. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to investigate the association between CYP3A4*1B (rs2740574 A… CONTINUE READING