• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2001
  • DOI:10.1002/jps.1123

CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies.

@article{Engman2001CYP3A4CA,
  title={CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies.},
  author={Helena Engman and Hans Lennern{\"a}s and Jan Taipalensuu and Charlotta Otter and Brith Leidvik and Per Artursson},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 11},
  pages={
          1736-51
        }
}
The aim of this study was to find a cell culture model of the intestinal epithelium for use in studies of CYP3A4-mediated first-pass metabolism of drugs and also for studies of the interplay between CYP3A4 metabolism and P-glycoprotein efflux. For this purpose, the expression of CYP3A4, CYP3A5, and MDR1 mRNA was studied in three cell lines of the normal human intestinal epithelium and three transformed cell lines of colonic (Caco-2) origin. Surprisingly, only transformed cell lines were induced… CONTINUE READING

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