CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.

@article{Cao2010CYP3ACS,
  title={CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.},
  author={Y-F Cao and Y Zhang and Jing-kui Li and G-B Ge and D Hu and H Liu and Ting Huang and Y L Wang and Z-Z Fang and D Sun and Haoli Huo and Jun Yin and Ling Yang},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2010},
  volume={40 1},
  pages={38-47}
}
Schizandrin is recognized as the major absorbed effective constituent of Fructus schisandrae, which is extensively applied in Chinese medicinal formula. The present study aimed to profile the phase I metabolites of schizandrin and identify the cytochrome P450 (CYP) isoforms involved. After schizandrin was incubated with human liver microsomes, three metabolites were isolated by high-performance liquid chromatography (HPLC) and their structures were identified to be 8(R)-hydroxyl-schizandrin, 2… CONTINUE READING