CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7.

  title={CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7.},
  author={Huan Qiu and Stefan Taudien and Holger Herlyn and J{\"u}rgen Schmitz and Yuan Zhou and Guopei Chen and Roberta Roberto and Mariano Rocchi and Matthias Platzer and Leszek Wojnowski},
  journal={Pharmacogenetics and genomics},
  volume={18 1},
OBJECTIVE CYP3A metabolizes 50% of currently prescribed drugs and is frequently involved in clinically relevant drug interactions. The understanding of roles and regulations of the individual CYP3A genes in pharmacology and physiology is incomplete. METHODS Using genomic sequences from 16 species we investigated the evolution of CYP3 genomic loci over a period of 450 million years. RESULTS CYP3A genes in amniota evolved from two ancestral CYP3A genes. Upon the emergence of eutherian mammals… CONTINUE READING
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