CYP2E1 and catalase influence ethanol sensitivity in the central nervous system.

@article{Vasiliou2006CYP2E1AC,
  title={CYP2E1 and catalase influence ethanol sensitivity in the central nervous system.},
  author={Vasilis Vasiliou and Thomas L Ziegler and Pequita Bludeau and Dennis R. Petersen and Frank J. Gonzalez and Richard A. Deitrich},
  journal={Pharmacogenetics and genomics},
  year={2006},
  volume={16 1},
  pages={51-8}
}
OBJECTIVES Genetic factors are known to influence the sensitivity and tolerance to ethanol in humans and laboratory animals. Ethanol is metabolized to acetaldehyde mainly by the alcohol dehydrogenase pathway (ADHs) and, to a lesser extent, by microsomal oxidization (CYP2E1) and the catalase-H2O2 system. METHODS In this study, we examined the role of CYP2E1 and catalase in ethanol metabolism and sensitivity, using transgenic knockout Cyp2e1(-/-) mice, acatalasemic (Cs/Cs) mice, double mutant… CONTINUE READING

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