CYP2D6 polymorphism in patients with eating disorders

@article{PeasLled2012CYP2D6PI,
  title={CYP2D6 polymorphism in patients with eating disorders},
  author={Eva Mar{\'i}a Pe{\~n}as-Lled{\'o} and Pedro Dorado and Zaida Ag{\"u}era and M{\'o}nica Gratac{\'o}s and Xavier Estivill and Fernando Fern{\'a}ndez-Aranda and Adri an Llerena},
  journal={The Pharmacogenomics Journal},
  year={2012},
  volume={12},
  pages={173-175}
}
CYP2D6 polymorphism is associated with variability in drug response, endogenous metabolism (that is, serotonin), personality, neurocognition and psychopathology. The relationship between CYP2D6 genetic polymorphism and the risk of eating disorders (ED) was analyzed in 267 patients with ED and in 285 controls. A difference in the CYP2D6 active allele distribution was found between these groups. Women carrying more than two active genes (ultrarapid metabolizers) (7.5 vs 4.6%) or two (67 vs 58.9… CONTINUE READING

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Pharmacogenomics and personality: role of CYP2D6 and implication for psychopathology

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