CYP2D6 polymorphism in a Mexican American population.

  title={CYP2D6 polymorphism in a Mexican American population.},
  author={Ricardo M Mendoza and Yu-Jui Yvonne Wan and Russell E. Poland and Mark W. Smith and Y. P. Zheng and Nancy Berman and Kevin M. Lin},
  journal={Clinical pharmacology and therapeutics},
  volume={70 6},
BACKGROUND Pharmacogenetic data are largely unavailable for Mexican Americans, despite being one of the largest populations in America. METHODS The CYP2D6 genotype (n = 349) and dextromethorphan hydroxylation phenotype (n = 285) were studied in 380 Mexican American subjects from Los Angeles County. RESULTS The allelic frequency was 22.8% for CYP2D6*2, 10.3% for CYP2D6*4, 7.4% for CYP2D6*10, 2.3% for CYP2D6*5, 1% for CYP2D6*XN (duplication), and <1% for CYP2D6*3 and CYP2D6*17. By using the… CONTINUE READING
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