CYP2D6 phenotype and the metabolism of nicotine and cotinine.

Abstract

That CYP2D6 activity is an important determinant of nicotine metabolism and that people who have abnormal CYP2D6 genes are poor metabolizers of nicotine has been reported in the medical literature. The aim of this study was to assess the role of CYP2D6 in nicotine metabolism. Specifically, we compared the clearance of stable isotope-labelled nicotine and… (More)

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Cite this paper

@article{Benowitz1996CYP2D6PA, title={CYP2D6 phenotype and the metabolism of nicotine and cotinine.}, author={Neil L Benowitz and Peyton Jacob and Eliseo J. P{\'e}rez-Stable}, journal={Pharmacogenetics}, year={1996}, volume={6 3}, pages={239-42} }