CYP2D6 is primarily responsible for the metabolism of clomiphene.

@article{Ghobadi2008CYP2D6IP,
  title={CYP2D6 is primarily responsible for the metabolism of clomiphene.},
  author={C. Ghobadi and A. Gregory and H. Crewe and A. Rostami-Hodjegan and M. Lennard},
  journal={Drug metabolism and pharmacokinetics},
  year={2008},
  volume={23 2},
  pages={
          101-5
        }
}
Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to clomiphene is variable and unpredictable. Tamoxifen is structurally related to clomiphene, and also shows considerable variation in response. CYP2D6 and CYP3A4 are major contributors to the metabolism of tamoxifen. The aim of the present work was to define the role of CYP2D6 and CYP3A4 in the in vitro metabolism of enclomiphene, regarded by some as the more active isomer of clomiphene. Enclomiphene… Expand

Paper Mentions

Observational Clinical Trial
The purpose of this study is to match the genetic component and clinical attributes of anovulatory patients with response to clomiphene treatment. By improving our… Expand
ConditionsInfertility, Female
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.
TLDR
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A comprehensive, rapid, sensitive, and specific analytical method for the quantification of (E)- and (Z)-isomers of clomiphene and their putative N-desethyl, N,N-didesethyl, 4-hydroxy, and 4-Hydroxy-N-desmethyl metabolites, and the N-oxides in human plasma has been newly developed, using HPLC-tandem mass spectrometry and stable isotope-labeled internal standards. Expand
Single‐Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease
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The conventional model‐dependent pharmacokinetics of clomiphene citrate isomers could not be determined due to a very flat terminal half‐life and the long‐tailed residence time, signifying the lipophilic nature and potentially extensive distribution of the compound. Expand
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