Corpus ID: 34792839

CYP2D6 Metabolizer Phenotypes in Patients Undergoing ECT After Antidepressant Therapy

  title={CYP2D6 Metabolizer Phenotypes in Patients Undergoing ECT After Antidepressant Therapy},
  author={H. Mirzakhani and Juli{\"e}t van Dormolen and K. Weide and H. Guchelaar and M. V. Noorden},
Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are common mental disorders. According to present guidelines, the effective antidepressant for treatment of MDD and BD for each individual patient is identified through trial and error switching in sequential treatments. A substantial proportion of depressive patients do not benefit from treatment due to ineffectiveness of medication therapy or incurring serious side effects. CYP2D6 variants are associated with metabolic… CONTINUE READING
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