CYP2D6 Gene Variants and Their Association with Breast Cancer Susceptibility

  title={CYP2D6 Gene Variants and Their Association with Breast Cancer Susceptibility},
  author={J. Abraham and M. Maranian and K. Driver and R. Platte and B. Kalmyrzaev and C. Luccarini and H. Earl and A. Dunning and P. Pharoah and C. Caldas},
  journal={Cancer Epidemiology, Biomarkers & Prevention},
  pages={1255 - 1258}
  • J. Abraham, M. Maranian, +7 authors C. Caldas
  • Published 2011
  • Medicine
  • Cancer Epidemiology, Biomarkers & Prevention
  • Background: The gene encoding the phase I enzyme cytochrome P4502D6 (CYP2D6) has been previously investigated for its potential predictive role in the efficacy of breast cancer treatments such as tamoxifen, but its role in breast cancer susceptibility is unclear. This study aims to evaluate the association between germ line variations in CYP2D6 and breast cancer susceptibility. Methods: DNA samples from 13,472 cases and controls were genotyped for seven known functional variants [minor allele… CONTINUE READING

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