CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel.

  title={CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel.},
  author={Daniel L Hertz and Somnath Singha Roy and Alison A. Motsinger-Reif and Amy A Drobish and L. Scott Clark and Ping Liao and Lisa A. Carey and Elizabeth Claire Dees},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={24 6},
BACKGROUND Paclitaxel-induced neuropathy is an adverse event that often leads to therapeutic disruption and patient discomfort. We attempted to replicate a previously reported association between increased neuropathy risk and CYP2C8*3 genotype. PATIENTS AND METHODS Demographic, treatment, and toxicity data were collected for paclitaxel-treated breast cancer patients who were genotyped for the CYP2C8*3 K399R (rs10509681) variant. A log-rank test was used in the primary analysis of European… CONTINUE READING
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