CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population.

@article{JurimaRomet1996CYP2C19GA,
  title={CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population.},
  author={Mall{\'e} Jurima-Romet and Joyce A. Goldstein and M J Lebelle and R{\'e}my A. Aubin and Brian C. Foster and W Walop and Anja Rode},
  journal={Pharmacogenetics},
  year={1996},
  volume={6 4},
  pages={329-39}
}
The CYP2C19-associated oxidation polymorphism of mephenytoin was investigated in an Inuit population living in the high Arctic of Canada. Results were obtained for 152 subjects, of whom 90 were unrelated to first degree relatives. Phenotyping was based on the capillary gas chromatographic determination of the S/R enantiomeric ratio in overnight urine collected after a dose of 100 mg (R,S)-mephenytoin. The phenotype was confirmed by determining the S/R enantiomeric ratio after acid treatment of… CONTINUE READING