CYP2C19*17 protects against metabolic complications of clozapine treatment.

@article{Piatkov2017CYP2C1917PA,
  title={CYP2C19*17 protects against metabolic complications of clozapine treatment.},
  author={Irina Piatkov and Dorgival Caetano and Yolinda Assur and Sue Lynn Lau and Micheline Coelho and Trudi Jones and Tristan Nguyen and Steven C. Boyages and Mark McLean},
  journal={The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry},
  year={2017},
  volume={18 7},
  pages={
          521-527
        }
}
OBJECTIVES Clozapine (CZ) is the most effective drug for managing treatment-resistant schizophrenic disorders. Its use has been limited due to adverse effects, which include weight gain and new-onset diabetes, but the incidence of these varies between patients. METHODS We investigated 187 Clozapine Clinic patients (of whom 137 consented for genotyping) for the presence of CYP2C19*17 and its association with CZ and norclozapine (NCZ) levels, and clinical outcomes. RESULTS Thirty-nine percent… CONTINUE READING

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