CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment.

@article{Lee2006CYP2B6IE,
  title={CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment.},
  author={A. Moses Lee and Sharon Miksys and Roberta M Palmour and Rachel F. Tyndale},
  journal={Neuropharmacology},
  year={2006},
  volume={50 4},
  pages={441-50}
}
CYP2B6 is a drug-metabolizing enzyme expressed in human tissues that can activate bupropion (a smoking cessation drug) and tobacco smoke nitrosamines and can inactivate drugs such as nicotine. Smokers have higher brain CYP2B6 protein levels compared to non-smokers but the cause of this elevation is unknown. We investigated the basal expression and the effect of chronic nicotine treatment on CYP2B6 protein in African Green monkey (Cercopithecus aethiops) brain. Basal expression of brain CYP2B6… CONTINUE READING