CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility

  title={CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility},
  author={Zhong-hai Yuan and Qian Liu and Ying Zhang and Hong-xing Liu and Jun Zhao and Ping Zhu},
  journal={Annals of Hematology},
CYP2B6 is a highly variable and polymorphic cytochrome P450 enzyme which plays a vital role in the degradation of some endogenous metabolites, xenobiotics, and harmful compounds. The 516G>T single nucleotide polymorphism (SNP) in exon 4 of CYP2B6 gene may change CYP2B6 enzyme activity and the gene expression in the liver. Carcinogens’ failure to be degraded by CYP2B6 may cause DNA injury and cancer. Here, we aimed to evaluate the association between genotype or allele of CYP2B6 516G>T SNP and… CONTINUE READING