CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

@article{Levran2013CYP2B6SA,
  title={CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.},
  author={Orna Levran and Einat Peles and Sara Christina Hamon and Matthew Randesi and M. William Adelson and Mary Jeanne Jeanne Kreek},
  journal={Addiction biology},
  year={2013},
  volume={18 4},
  pages={
          709-16
        }
}
Adequate methadone dosing in methadone maintenance treatment (MMT) for opioid addiction is critical for therapeutic success. One of the challenges in dose determination is the inter-individual variability in dose-response. Methadone metabolism is attributed primarily to cytochrome P450 enzymes CYP3A4, CYP2B6 and CYP2D6. The CYP2B6*6 allele [single nucleotide polymorphisms (SNPs) 785A>G (rs2279343) and 516G>T (rs3745274)] was associated with slow methadone metabolism. To explore the effects of… CONTINUE READING
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