CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people

@article{Binnington2012CYP2A6AC,
  title={CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people},
  author={Matthew J. Binnington and Andy Z. X. Zhu and Caroline C. Renner and Anne P. Lanier and Dorothy K. Hatsukami and Neal L. Benowitz and Rachel F. Tyndale},
  journal={Pharmacogenetics and Genomics},
  year={2012},
  volume={22},
  pages={429–440}
}
  • Matthew J. Binnington, Andy Z. X. Zhu, +4 authors Rachel F. Tyndale
  • Published 2012
  • Medicine, Biology
  • Pharmacogenetics and Genomics
  • ObjectivesAlaska Native (AN) people have a high prevalence of tobacco use and associated morbidity and mortality when compared with the general USA population. Variations in the CYP2A6 and CYP2B6 genes, encoding enzymes responsible for nicotine metabolic inactivation and procarcinogen activation, have not been characterized in AN and may contribute toward the increased risk. MethodsAN people (n=400) residing in the Bristol Bay region of South Western Alaska were recruited for a cross-sectional… CONTINUE READING

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