CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.

@article{Nowell2002CYP2A6AD,
  title={CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.},
  author={Susan A. Nowell and Carol Sweeney and George Hammons and Fred F. Kadlubar and Nicholas P. Lang},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2002},
  volume={11 4},
  pages={377-83}
}
Cytochrome P450 2A6 (CYP2A6) catalyzes the metabolic activation of several procarcinogens including dietary and environmental nitrosamines, and the involvement of CYP2A6 in cancer development has been postulated. CYP2A6 phenotype was determined using caffeine as a probe drug in individuals participating in a case-control study of colorectal cancer (127 cases and 333 controls matched on age, gender, race, and geographic region). Conversion of the caffeine metabolite 1,7-dimethylxanthine (17X) to… CONTINUE READING
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