CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways.

Abstract

Germ cell sex is defined by factors derived from somatic cells. CYP26B1 is known to be a male sex-promoting factor that inactivates retinoic acid (RA) in somatic cells. In CYP26B1-null XY gonads, germ cells are exposed to a higher level of RA than in normal XY gonads and this activates Stra8 to induce meiosis while male-specific gene expression is… (More)
DOI: 10.1016/j.ydbio.2014.02.013

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@article{Saba2014CYP26B1PM, title={CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways.}, author={Rie Saba and Quan Wu and Yumiko Saga}, journal={Developmental biology}, year={2014}, volume={389 2}, pages={173-81} }