CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder?

@article{Braam2013CYP1A2PI,
  title={CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder?},
  author={Wiebe Braam and Henry Keijzer and Harry A J Struijker Boudier and Robert Didden and Marcel G. Smits and Leopold M G Curfs},
  journal={Journal of intellectual disability research : JIDR},
  year={2013},
  volume={57 11},
  pages={993-1000}
}
BACKGROUND In some of our patients with intellectual disabilities (ID) and sleep problems, the initial good response to melatonin disappeared within a few weeks after starting treatment. In these patients melatonin levels at noon were extremely high (>50 pg/ml). We hypothesise that the disappearing effectiveness is associated with slow metabolisation of melatonin because of a single nucleotide polymorphism (SNP) of CYP1A2. METHOD In this pilot study we analysed DNA extracted from saliva… CONTINUE READING
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