CYP1A1 polymorphism and risk of gynecological malignancy in Japan.

Abstract

The incidence of endometrial cancer and ovarian cancer in Japan has been increasing in recent years. Results of epidemiologic studies suggest that the onset and multiplication of these cancers are associated with estrogen. Estrogens are metabolized by cytochrome P450 1A1 (CYP1A1) and converted into catecholestrogens, which are carcinogens. CYP1A1 has… (More)

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Cite this paper

@article{Sugawara2003CYP1A1PA, title={CYP1A1 polymorphism and risk of gynecological malignancy in Japan.}, author={Teruo Sugawara and Emi M. Nomura and Tamotsu Sagawa and Naoya Sakuragi and S. Shouichi Fujimoto}, journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society}, year={2003}, volume={13 6}, pages={785-90} }