CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes.

@article{Heuvel1993CYP1A1ML,
  title={CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes.},
  author={John Patrick Vanden Heuvel and George C. Clark and Claudia L. Thompson and Z McCoy and Chris R. Miller and George W. Lucier and Douglas A. Bell},
  journal={Carcinogenesis},
  year={1993},
  volume={14 10},
  pages={2003-6}
}
Accurate human risk assessment requires sensitive methods to evaluate dose-response relationships, especially following low level exposures. We have developed a reverse transcriptase polymerase chain reaction (RT-PCR) method to quantitative cytochrome P450-1A1 (CYP1A1) mRNA levels in human blood lymphocytes. Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through… CONTINUE READING

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