CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women.

Abstract

We have recently shown that cigarette smoking is associated with lesser responses to potent antiretroviral therapies. Certain Cytochrome P-450 enzymes activate compounds derived from tobacco smoke into toxic forms that may promote HIV-1 gene expression through promotion of DNA-adduct formation by the oxidation of chemical constituents of cigarette smoke… (More)
DOI: 10.1521/aeap.2009.21.3_supp.81

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@article{Feldman2009CYP1A1GM, title={CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women.}, author={David N Feldman and Joseph Feldman and Ruth Greenblatt and Kathryn M Anastos and Leigh J Pearce and Mardge H. Cohen and Stephen J Gange and Suzanne M Leanza and Robbie Burk}, journal={AIDS education and prevention : official publication of the International Society for AIDS Education}, year={2009}, volume={21 3 Suppl}, pages={81-93} }