CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy.

@article{Landi2005CYP1A1AC,
  title={CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy.},
  author={Maria Teresa Landi and Andrew Bergen and Andrea A. Baccarelli and Donald J. Patterson and Jean A. Grassman and Monica Ter-Minassian and Paolo Mocarelli and Neil E. Caporaso and Scott A. Masten and Angela Cecilia Pesatori and Gary S. Pittman and Douglas A. Bell},
  journal={Toxicology},
  year={2005},
  volume={207 2},
  pages={191-202}
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. We investigated the effect of CYP1A1 and CYP1B1 variant genotypes and haplotypes on CYP1A1 and CYP1B1 mRNA expression and ethoxyresorufin-O-deethylase (EROD) activity in lymphocytes from 121 subjects from the Seveso population, Italy, accidentally exposed to TCDD in 1976. The 3'UTR 3801T>C and I462V variants of CYP1A1 were present in 16% and 6% of the… CONTINUE READING