CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women.

@article{Amorim2002CYP1A1GA,
  title={CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women.},
  author={L{\'i}dia da Fonte de Amorim and Ana Carolina Rossini and Gulnar Azevedo Silva Mendonça and Priscila Falagan Lotsch and Tatiana de Almeida Sim{\~a}o and Cl{\'a}udia Vit{\'o}ria de Moura Gallo and Lu{\'i}s Carlos Nunes Pinto},
  journal={Cancer letters},
  year={2002},
  volume={181 2},
  pages={
          179-86
        }
}
The frequency of CYP1A1 (CYP1A1*2A), GSTM1, and GSTT1 polymorphisms, as well as the main risk factors associated with breast cancer were studied in Brazilian women, with malignant breast cancer (n=128), or age-matched controls (n=256). Only a family history of breast cancer presented a significant risk (OR=3.00, CI=1.27-7.06). Among non-whites, the CYP1A1*2A allele was underrepresented among patients. Statistical analysis indicated that this polymorphism may decrease the risk of breast cancer… CONTINUE READING
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