CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.

@article{Gajecka2005CYP1A1CC,
  title={CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.},
  author={Marzena Gajecka and Malgorzata Rydzanicz and Renata Jaskula-Sztul and Maciej Kujawski and Witold Szyfter and Krzysztof Szyfter},
  journal={Mutation research},
  year={2005},
  volume={574 1-2},
  pages={112-23}
}
Polymorphisms in the selected genes controlling carcinogen metabolism (CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1, GSTT1) considered separately or in different combinations, were investigated for an association with tobacco smoke-associated squamous cell carcinoma (SCC) of the larynx. The case-control study was performed in 289 patients with laryngeal SCC and in 316 cancer-free controls; all were Caucasian males from the same region of Poland and current tobacco smokers. The DNA samples were genotyped… CONTINUE READING

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