CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.

@article{Ma2007CYP1AIA,
  title={CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.},
  author={Qiang Ma and A. Y. Lu},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 7},
  pages={
          1009-16
        }
}
  • Qiang Ma, A. Y. Lu
  • Published 2007 in
    Drug metabolism and disposition: the biological…
CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. CYP1As are highly inducible by PAHs and halogenated aromatic hydrocarbons via aryl hydrocarbon receptor-mediated gene transcription. The impact of CYP1A induction on the carcinogenic and toxic potentials of environmental, occupational, dietary… CONTINUE READING
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