CYP19 (aromatase) haplotypes and endometrial cancer risk.

  title={CYP19 (aromatase) haplotypes and endometrial cancer risk.},
  author={Randi A. Paynter and Susan E. Hankinson and Graham A. Colditz and Peter Kraft and David J. Hunter and Immaculata de Vivo},
  journal={International journal of cancer},
  volume={116 2},
Endogenous estrogen exposure is an important determinant of endometrial cancer risk. Aromatase, encoded by CYP19, catalyzes the aromatization of androstenedione and testosterone to estrone and estradiol, respectively. Several common genetic polymorphisms in CYP19 have been identified, including a TCT insertion/deletion and a (TTTA)(n) repeat polymorphism in intron IV as well as a 3'UTR C/T polymorphism. We evaluated these 3 polymorphisms plus an additional 9 noncoding polymorphisms as… CONTINUE READING