CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes.

  title={CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes.},
  author={Franca Maria Buratti and Maria Teresa Volpe and Annarita Meneguz and Luciano Vittozzi and Emanuela Testai},
  journal={Toxicology and applied pharmacology},
  volume={186 3},
The bioactivation of azinphos-methyl (AZIN), chlorpyrifos (CPF), diazinon (DIA), and parathion (PAR), four widely used organophosphorothioate (OPT) pesticides has been investigated in human liver microsomes (HLM). In addition, the role of human cytochrome P450 (CYPs) in OPT desulfuration at pesticide levels representative of human exposure have been defined by means of correlation and immunoinhibition studies. CYP-mediated oxon formation from the four OPTs is efficiently catalyzed by HLM… CONTINUE READING

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