CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.

@article{Ponnoth2012CYPepoxygenasesCT,
  title={CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.},
  author={Dovenia S. Ponnoth and Mohammed A Nayeem and Stephen L. Tilley and Catherine A. Ledent and S Jamal Mustafa},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2012},
  volume={303 10},
  pages={R1003-10}
}
Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hypothesized that ATP-sensitive K(+) (K(ATP)) channels play an important role in A(2A)AR-mediated relaxation. Organ bath and Western blot experiments were done using isolated aorta from A(2A)KO and corresponding wild-type (WT) mice. Aortic rings from WT and A(2A) knockout (KO) mice were precontracted… CONTINUE READING

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