CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.

@article{Yang2014CYLDRS,
  title={CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.},
  author={Yunfan Yang and Min Liu and Dengwen Li and Jie Ran and Jinmin Gao and Shaojun Suo and Shao-cong Sun and Jun Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 6},
  pages={2158-63}
}
Oriented cell division is critical for cell fate specification, tissue organization, and tissue homeostasis, and relies on proper orientation of the mitotic spindle. The molecular mechanisms underlying the regulation of spindle orientation remain largely unknown. Herein, we identify a critical role for cylindromatosis (CYLD), a deubiquitinase and regulator of microtubule dynamics, in the control of spindle orientation. CYLD is highly expressed in mitosis and promotes spindle orientation by… CONTINUE READING
37 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Similar Papers

Loading similar papers…