CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

@article{Wickstrm2010CYLDNR,
  title={CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin},
  author={Sara A Wickstr{\"o}m and Katarzyna Chmielarska Masoumi and Saadi Khochbin and Reinhard F{\"a}ssler and Ramin Massoumi},
  journal={The EMBO Journal},
  year={2010},
  volume={29},
  pages={131 - 144}
}
CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating enzyme that was shown to regulate cell proliferation, cell survival and inflammatory responses, mainly through inhibiting NF-kappaB signalling. Here we show that CYLD controls cell growth and division at the G(1)/S-phase as well as cytokinesis by associating with alpha-tubulin and microtubules through its CAP-Gly domains. Translocation of… CONTINUE READING

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