CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways

  title={CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways},
  author={Hengning Ke and C. Augustine and V. Gandham and J. Jin and D. Tyler and S. K. Akiyama and R. Hall and J. Zhang},
  journal={The Journal of investigative dermatology},
  pages={221 - 229}
  • Hengning Ke, C. Augustine, +5 authors J. Zhang
  • Published 2013
  • Biology, Medicine
  • The Journal of investigative dermatology
  • The molecular mechanisms mediating CYLD tumor suppressor function appear to be manifold. Here, we demonstrated that, in contrast to the increased levels of pJNK, CYLD was decreased in a majority of melanoma cell lines and tissues examined. Exogenous expression of CYLD but not its catalytically deficient mutant markedly inhibited melanoma cell proliferation and migration in vitro and subcutaneous tumor growth in vivo. In addition, the melanoma cells expressing exogenous CYLD were unable to form… CONTINUE READING
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