CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATS

@article{Laupacis1983CYCLOSPORINPD,
  title={CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATS},
  author={Andreas Laupacis and C. Gardell and John Dupre and Calvin R. Stiller and Ph. Thibert},
  journal={The Lancet},
  year={1983},
  volume={321},
  pages={10-12}
}
Cyclosporin (U.S.A.N. cyclosporine) was used prophylactically to suppress the development of insulin-dependent diabetes mellitus in BB Wistar rats. In this rat strain diabetes spontaneously develops between 60 and 120 days of age and this condition resembles human type 1 diabetes. In 30 (75%) out of 40 control rats glycosuria and hyperglycaemia developed and these rats became insulin-dependent. Their pancreases showed partial to complete destruction of the islets of Langerhans by lymphocytic… CONTINUE READING
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