CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer.

@article{Bala2001CYCLINDA,
  title={CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer.},
  author={Shashi Bala and P{\"a}ivi Peltom{\"a}ki},
  journal={Cancer research},
  year={2001},
  volume={61 16},
  pages={6042-5}
}
Hereditary nonpolyposis colorectal cancer is associated with inherited defects in DNA mismatch repair. Clinical variation even in cases with identical predisposing mutations suggests the existence of other factors contributing to the phenotype. We addressed the modifying role of the common A/G polymorphism in exon 4 and the alternatively spliced transcripts a and b of the CCND1 gene encoding cyclin D1 in a series of 146 affected carriers of 10 MLH1 and 3 MSH2 mutations. No correlation was… CONTINUE READING