CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis.

  title={CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis.},
  author={Xijun Wang and Peng Liao and Xiongwei Fan and Y. Wan and Yuliang Wang and Yongqing Li and Zhigang Jiang and Xiangli Ye and Xiao-yang Mo and Karen Ocorr and Yaqi Deng and Xinjiang Wu and Wuzhou Yuan},
  journal={Current molecular medicine},
  volume={13 8},
Apoptosis is a widespread phenomenon and its dysregulation may result in a variety of human pathologies, such as cancer, autoimmune diseases and neurodegenerative disorders. CXXC-type zinc finger protein 5 (CXXC5) is commonly considered as a tumor suppressor undergoing deregulation or deletion in hematonosis. But it has implied involvement in apoptosis indirectly and the molecular mechanism remains unknown. In this study, we investigated CXXC5-induced apoptosis as well as its underlying… CONTINUE READING