CXXC5: A novel regulator and coordinator of TGF‐β, BMP and Wnt signaling

@inproceedings{Xiong2018CXXC5AN,
  title={CXXC5: A novel regulator and coordinator of TGF‐β, BMP and Wnt signaling},
  author={Xiangyang Xiong and Shuo Tu and Jianbin Wang and Shiwen Luo and Xiaohua Yan},
  booktitle={Journal of cellular and molecular medicine},
  year={2018}
}
CXXC5 is a member of the CXXC-type zinc-finger protein family. Proteins in this family play a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene promoters through their characteristic CXXC domain. CXXC5 is a short protein (322 amino acids in length) that does not have any catalytic domain, but is able to bind to DNA and act as a transcription factor and epigenetic factor through protein-protein interactions. Intriguingly, increasing evidence indicates that… CONTINUE READING
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