CXCR7 mediates SDF1-induced melanocyte migration.

@article{Lee2013CXCR7MS,
  title={CXCR7 mediates SDF1-induced melanocyte migration.},
  author={Eunkyung G. Lee and Jiyeon Han and Kwangmi Ko Kim and Hyunjung Choi and Eun-Gyung Cho and Tae Ryong Lee},
  journal={Pigment cell & melanoma research},
  year={2013},
  volume={26 1},
  pages={58-66}
}
Melanoblasts are derived from the neural crest and migrate to the dermal/epidermal border of skin and hair bulges. Although melanoblast migration during embryogenesis has been well investigated, there are only a few reports regarding the migration of mature melanocytes. Here, we demonstrate that a chemokine, stromal-derived factor-1 (SDF1, also known as CXCL12), and one of its receptor CXCR7 regulate normal human epidermal melanocyte (NHEM) migration. We found that SDF1 induces the directional… CONTINUE READING
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