CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells.

@article{Monnier2012CXCR7IU,
  title={CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells.},
  author={Justin Monnier and Mathieu Boissan and Annie L'helgoualc'h and Marie-Lise Lacombe and Bruno Turlin and Jessica Zucman-Rossi and Nathalie Th{\'e}ret and Claire Piquet-Pellorce and Michel Samson},
  journal={European journal of cancer},
  year={2012},
  volume={48 1},
  pages={
          138-48
        }
}
Development of hepatocellular carcinoma (HCC) is a complex and progressive disease that involves cycles of liver cell death, inflammation, and tissue regeneration/remodelling. Chemokines and chemokine receptors play numerous and integral roles in the disease progression of HCC. Here we investigated the novel chemokine receptor CXCR7/RDC1 in HCC progression, its two known ligands CXCL12 and CXCL11, as well as the other CXCL12 receptor, CXCR4. Our results show that in a cohort of 408 human HCCs… CONTINUE READING

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