CXCR7 impact on CXCL12 biology and disease.

@article{SnchezMartn2013CXCR7IO,
  title={CXCR7 impact on CXCL12 biology and disease.},
  author={Lorena S{\'a}nchez-Mart{\'i}n and Paloma S{\'a}nchez-Mateos and Carlos Caba{\~n}as},
  journal={Trends in molecular medicine},
  year={2013},
  volume={19 1},
  pages={
          12-22
        }
}
It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive therapeutic target for autoimmune diseases and cancer. CXCR7/CXCR4 heterodimerization, β-arrestin-mediated signaling, and modulation of CXCL12… CONTINUE READING
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