CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity

@inproceedings{CruzOrengo2011CXCR7AP,
  title={CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity},
  author={Lillian Cruz-Orengo and Y. Chen and Joong Hee Kim and Denise A Dorsey and S K Song and Robyn S Klein},
  booktitle={Journal of Neuroinflammation},
  year={2011}
}
Multiple Sclerosis (MS) is characterized by the pathological trafficking of leukocytes into the central nervous system (CNS). Using the murine MS model, experimental autoimmune encephalomyelitis (EAE), we previously demonstrated that antagonism of the chemokine receptor CXCR7 blocks endothelial cell sequestration of CXCL12, thereby enhancing the abluminal localization of CXCR4-expressing leukocytes. CXCR7 antagonism led to decreased parenchymal entry of leukocytes and amelioration of ongoing… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS
19 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…