CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

  title={CXCR7 Functions as a Scavenger for CXCL12 and CXCL11},
  author={Ulrike Naumann and Elisabetta Cameroni and M. Mandela Pr{\"u}nster and Harsha Mahabaleshwar and Erez Raz and Hans-Guenter Zerwes and Antal Rot and Marcus Thelen},
  booktitle={PloS one},
BACKGROUND CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy activity in fish. Here we investigated the two propositions in human tissues. METHODOLOGY/PRINCIPAL… CONTINUE READING
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