CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma.

@article{Gao2012CXCR6UC,
  title={CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma.},
  author={Qiang Gao and Ying-Jun Zhao and Xiaoying Wang and Shuang-jian Qiu and Ying-hong Shi and Jian Xun Sun and Yong Yi and Jie-yi Shi and Guo-Ming Shi and Zhen-bin Ding and Yong-sheng Xiao and Zhong-Hua Zhao and Jian Zhou and Xianghuo He and Jia Fan},
  journal={Cancer research},
  year={2012},
  volume={72 14},
  pages={3546-56}
}
CXC chemokines and their cognate receptors have been implicated widely in cancer pathogenesis. In this study, we report a critical causal relationship between CXCR6 expression and tumorigenesis in the setting of human hepatocellular carcinoma (HCC). Among the CXC chemokine receptors, only CXCR6 was detected in all the hepatoma cell lines studied. Moreover, in HCC tissue, CXCR6 expression was significantly higher than in noncancerous liver tissues. Reduction of CXCR6 or its ligand CXCL16 in… CONTINUE READING

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