CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway.

@article{Wang2008CXCR6IP,
  title={CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway.},
  author={Jianhua Wang and Yi Lu and Jingchen Wang and Alisa Erika Koch and Jian Zhang and Russell S Taichman},
  journal={Cancer research},
  year={2008},
  volume={68 24},
  pages={
          10367-76
        }
}
Previous studies show that the chemokine CXCL16 and its receptor CXCR6 are likely to contribute to prostate cancer (PCa). In this investigation, the role of the CXCR6 receptor in PCa was further explored. CXCR6 protein expression was examined using high-density tissue microarrays and immunohistochemistry. Expression of CXCR6 showed strong epithelial staining that correlated with Gleason score. In vitro and in vivo studies in PCa cell lines suggested that alterations in CXCR6 expression were… CONTINUE READING

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