CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering.

@article{Ayala2017CXCR5DependentEO,
  title={CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering.},
  author={Victor I. Ayala and Claire Deleage and Matthew T Trivett and Sumiti Jain and Lori V. Coren and Matthew W Breed and Joshua A. Kramer and James Arthur Thomas and Jacob D Estes and Jeffrey D Lifson and David E. Ott},
  journal={Journal of virology},
  year={2017},
  volume={91 11}
}
Follicular helper CD4 T cells, TFH, residing in B-cell follicles within secondary lymphoid tissues, are readily infected by AIDS viruses and are a major source of persistent virus despite relative control of viral replication. This persistence is due at least in part to a relative exclusion of effective antiviral CD8 T cells from B-cell follicles. To determine whether CD8 T cells could be engineered to enter B-cell follicles, we genetically modified unselected CD8 T cells to express CXC… CONTINUE READING
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