CXCR4-transduced mesenchymal stem cells protect mice against graft-versus-host disease.

Abstract

Mesenchymal stem cells (MSCs) possessing immunoregulatory activities have been evaluated in the treatment of graft-versus-host disease (GVHD). However, the immunomodulatory effects of MSCs are not always successfully achieved in some animal models, and this deficiency may be caused in part by poor homing of these cells to hematopoietic tissues. In this… (More)
DOI: 10.1016/j.imlet.2012.01.015

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@article{Chen2012CXCR4transducedMS, title={CXCR4-transduced mesenchymal stem cells protect mice against graft-versus-host disease.}, author={Wei Chen and Miao Li and Zhenyu Li and Zhiling Yan and Hai Cheng and Bin Pan and Jiang Cao and Chong Chen and Ling-yu Zeng and Kailin Xu}, journal={Immunology letters}, year={2012}, volume={143 2}, pages={161-9} }