CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.

  title={CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.},
  author={Peter Gassmann and J{\"o}rg Haier and Kerstin Schl{\"u}ter and Britta Domikowsky and Claudia Wendel and Ulrike Wiesner and Robert Christof Kubitza and Rainer Engers and Stephan Schneider and Bernhard Homey and Anja Mueller},
  volume={11 7},
Recent studies have demonstrated that the chemokine receptor CXCR4 plays a crucial role in organ-specific metastasis formation. Although a variety of studies showed the expression of chemokine receptors, in particular, CXCR4, by gastrointestinal tumors, the precise mechanisms of chemokine receptor-mediated homing of cancer cells to specific sites of metastasis remained elusive. Here, we used liver metastatic human HEP-G2 hepatoma and HT-29LMM colon cancer cells expressing functional CXCR4 to… CONTINUE READING


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