CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo

@article{Lapteva2005CXCR4KB,
  title={CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo},
  author={Natalia Lapteva and An-gang Yang and Denise E Sanders and Randall W Strube and Si-Yi Chen},
  journal={Cancer Gene Therapy},
  year={2005},
  volume={12},
  pages={84-89}
}
Breast cancer cells express the chemokine receptor CXCR4 and frequently metastasize to organs with an abundant source of the CXCR4 ligand, stromal cell-derived factor 1 (SDF-1). The chemokine receptor CXCR4 plays an active role in the metastasis of breast cancer. Here, we show that a small interfering RNA (siRNA) against CXCR4 effectively downregulates CXCR4 expression in human MDA-MB-231 breast cancer cells, leading to significant decrease in breast cancer cell invasion and adhesion. It was… CONTINUE READING

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